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Synlett 2014; 25(6): 751-759
DOI: 10.1055/s-0033-1340627
DOI: 10.1055/s-0033-1340627
synpacts
Artemisinin: A Case Study in the Evolution of Synthetic Strategy
Weitere Informationen
Publikationsverlauf
Received: 20. November 2013
Accepted after revision: 10. Dezember 2013
Publikationsdatum:
23. Januar 2014 (online)
Abstract
Artemisinin represents one of the most important discoveries in the fight against malaria over the last 50 years. As the first endoperoxide-containing natural product, artemisinin has attracted chemists and biologists alike with its potent activity and rapid onset against malaria-causing Plasmodium species. Since its disclosure in 1979, artemisinin has been the subject of several elegant syntheses. Herein, the evolution of synthetic strategy is discussed in the context of artemisinin.
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