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Synlett 2013; 24(12): 1549-1554
DOI: 10.1055/s-0033-1339193
DOI: 10.1055/s-0033-1339193
letter
Synthesis of 2-Aryl Benzothiazoles via K2S2O8-Mediated Oxidative Condensation of Benzothiazoles with Benzylamines
Further Information
Publication History
Received: 17 April 2013
Accepted after revision: 18 May 2013
Publication Date:
17 June 2013 (online)
Abstract
A novel way to synthesize 2-arylbenzothiazoles is described. Reactions of benzothiazoles with diverse benzylamines in the presence of K2S2O8 and KOt-Bu in DMSO–H2O afforded the desired 2-arylbenzothiazoles in good yields. It is notable that no transition-metal catalyst is needed in this reaction. Compared with other known methods, this method of synthesizing 2-arylbenzothiazoles can be advantageous in cases where substituted benzothiazoles and benzylamines are readily available.
Supporting Information
- Experimental procedures, characterization data, and copies of 1H NMR and 13C NMR spectra for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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