Toward the Total Synthesis of Divergolides C and D

Abstract

The divergolides are a family of structurally unprecedented ansa macrocycles. We describe a synthetic strategy toward divergolides C and D that hinges on the biomimetic diversification of a common intermediate. An advanced precursor that incorporates all the carbon atoms of divergolide C and D is presented, and atrop­isomerism in a sterically crowded acyl naphthalene is studied.

Key words

natural products - ansamycins - macrolides - divergent synthesis - atropisomerism

• References


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