Peripheral Serous Pigment Epithelial Detachment and Retinal Detachment Presumably Associated with Hydrochlorothiazide Use

Background

Sulfa-derivatives have been associated with acute transient myopia, angle closure glaucoma (ACG), and ciliochoroidal effusion syndrome (CCES) but not with pigment epithelial detachment (PED) or serous retinal detachment (SRD) [1], [2], [3], [4]. We report a case with features of CCES as well as a peripheral serous PED (SPED) and SRD which developed while taking hydrochlorothiazide, a sulfa-derivative.

• References

• 1 Ikeda N, Ikeda T, Nagata M et al. Pathogenesis of transient high myopia after blunt eye trauma. Ophthalmol 2002; 109: 501-507
• 2 Ikeda N, Ikeda T, Nagata M et al. Ciliochoroidal effusion syndrome induced by sulfa derivatives. Arch Ophthalmol 2001; 120: 1775
• 3 Viet Tran H, Ravinet E, Schnyder C et al. Blood-brain barrier disruption associated with topiramate-induced angle-closure glaucoma of acute onset. Klin Monatsbl Augenheilkd 2006; 223: 425-427
• 4 Abtahi MA, Abtahi SH, Fazel F et al. Topiramate and the vision: a systematic review. Clin Ophthalmol 2012; 6: 117-131
• 5 Gemenetzi M, De Salvo G, Lotery AJ. Central serous chorioretinopathy: an update on pathogenesis and treatment. Eye 2010; 24: 1743-1756
• 6 Ross A, Ross AH, Mohamed Q. Review and update of central serous chorioretinopathy. Curr Opin Ophthalmol 2011; 22: 166-173
• 7 Yannuzzi LA, Shakin JL, Fisher YL et al. Peripheral retinal detachments and retinal pigment epithelial atrophic tracts secondary to central serous pigment epitheliopathy. Ophthalmol 1984; 91: 1554-1572
• 8 Elagouz M, Stanescu-Segall D, Jackson TL. Uveal effusion syndrome. Surv Ophthalmol 2010; 55: 134-145
• 9 Wolfensberger TJ, Tufail A. Systemic disorders associated with detachment of the neurosensory retina and retinal pigment epithelium. Curr Opin Ophthalmol 2000; 11: 455-461
• 10 Naranjo CA, Busto U, Sellers EM et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-245