Synlett 2013; 24(1): 57-60
DOI: 10.1055/s-0032-1317709
letter
© Georg Thieme Verlag Stuttgart · New York

Nucleophilic 5-endo-trig Cyclization of 3,3-Difluoroallylic Ketone Enolates: Synthesis of 5-Fluorinated 2-Alkylidene-2,3-dihydrofurans

Takeshi Fujita
a   Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan   Fax: +81(29)8534237   Email: junji@chem.tsukuba.ac.jp
,
Kotaro Sakoda
b   Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
,
Masahiro Ikeda
a   Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan   Fax: +81(29)8534237   Email: junji@chem.tsukuba.ac.jp
,
Masahiro Hattori
a   Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan   Fax: +81(29)8534237   Email: junji@chem.tsukuba.ac.jp
,
Junji Ichikawa*
a   Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan   Fax: +81(29)8534237   Email: junji@chem.tsukuba.ac.jp
› Author Affiliations
Further Information

Publication History

Received: 11 October 2012

Accepted after revision: 08 November 2012

Publication Date:
10 December 2012 (online)

 


Abstract

3,3-Difluoroallylic ketones readily undergo nucleophilic 5-endo-trig cyclization through their metal enolates to afford 5-fluor­inated 2-alkylidene-2,3-dihydrofurans. O-Cyclization exclusively occurred via intramolecular substitution of the vinylic fluorines.


gem-Difluoroalkenes (1,1-difluoro-1-alkenes) have unique reactivities toward nucleophiles, which are based on their electron-deficient and highly polarized nature. They facilitate extraordinary substitution reactions, which hardly proceed in normal alkenes.[ 1 ] Difluoroalkenes readily undergo vinylic nucleophilic substitution (SNV) via addition to electrophilic difluoromethylene carbons and subsequent fluoride elimination. We have already reported syntheses of ring-fluorinated heterocycles by conducting the SNV reaction of difluoroalkenes in an intra-molecular fashion.[ 2 ] As well as sp3 heteroatom and carbon nucleophiles,[ 3 ] sp2 nucleophiles[ 4 ] have also participated in the 6-endo-trig cyclization to afford six-membered heterocycles (Scheme [1], eq 1). Furthermore, the high reactivity of 1,1-difluoro-1-alkenes has even allowed normally ‘disfavored’ 5-endo-trig cyclization,[5] [6] [7] [8] [9] which provides scaffolds for 2-fluoro-4,5-dihydroheteroles and 2-fluorobenzoheteroles (Scheme [1], eq 2).[ 10 ] Addressing the next challenge to the ‘disfavored’ process, we herein demonstrate the 5-endo-trig cyclization with the metal enolates of 3,3-difluoroallylic ketones, which are sp2 atom-based ambident nucleophiles and rotationally restricted around the anionic centers (Scheme [1], eq 3). This process efficiently provides 2-alkylidene-2,3-dihydrofurans[ 11 ] by (i) constructing the heterocyclic ring and (ii) introducing a fluorine substituent and an alkylidene group onto the prescribed ring carbon.

The starting 3,3-difluoroallylic ketones are readily accessible through the following chemoselective difluoromethylenation protocol. 1,3-Ketoaldehydes 1, the precursors of 3,3-difluoroallylic ketones 2, were synthesized by the acylation of either morpholine enamines 3 or metal N-tert-butyl enamides prepared by deprotonation of imines 4, followed by hydrolysis (Scheme [2]).[ 12 ] Finally, difluoroallylic ketones 2 were obtained in moderate to high yield (27–86%) via difluoromethylenation of ketoaldehydes 1 by a triaminophosphonium difluoromethylide, generated in situ from dibromodifluoromethane and tris(dimethylamino)phosphine (Scheme [2]).[ 13 ] Success of the exclusively selective difluoromethylenation of 1 was due to the much higher reactivity of formyl groups compared to ­ketone carbonyl groups.

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Scheme 1Intramolecular cyclization of gem-difluoroalkenes
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Scheme 2 Synthesis of 3,3-difluoroallylic ketones 2

First, we sought bases suitable for the enolate formation and the subsequent 5-endo-trig cyclization by using difluoroallylic ketone 2a as a model substrate (Table [1]). Lithium diisopropylamide (LDA) afforded the O-cyclization product 5a as a single isomer, albeit in low yield, while the C-cyclization product 6a was not detected at all (Table [1], entry 1).[ 14 ] Two-fold increase in the amount of LDA (2 equiv) turned out to be effective for the cyclization (Table [1], entry 2). Also, potassium hydride (1 equiv) exclusively gave 5a and drastically improved its yield up to 79% (Table [1], entry 3). As in the case of LDA, use of doubled amounts of potassium hydride (2 equiv) was highly effective, leading to a 91% yield of the desired dihydrofuran 5a (Table [1], entry 4). Thus, the nucleophilic 5-endo-trig cyclization successfully proceeded even with rotationally restricted sp2 nucleophiles in 2a. This is likely due to the large polarization of the CF2=C moiety.[ 10a ]

Table 1 Screening of Bases Suitable for 5-endo-trig Cyclization of 2a

Entry

Base (equiv)

Time

Yield of 5a (%)

Yield of 6a (%)

1

LDA (1.0)

5 h

29

a

2

LDA (2.0)

4 h

42

a

3

KH (1.0)

2 h

79

a

4

KH (2.0)

2 h

91

a

a Not detected.

Table 2 5-endo-trig Cyclization of 3,3-Difluoroallylic Ketones 2

Entry

Time (h)

Product

Yield of 5 (%)

 1

2

5a 91

 2

2

5b 97

 3

2

5c 83

 4

2

5d 75

 5

2

5e 98

 6

2

5f 97

 7

21

5g 91

 8

5

5h 91

 9

2

5i 94

10a

3

5j 97

a Pyridine was used as the solvent instead of THF.

The optimized conditions obtained above for 2a were successfully applied to the cyclizations of a variety of difluoroallylic ketones 2 (Table [2]).[15] [16] Ketones 2bg, which are dimethylated at the allylic position, gave corresponding fluorine-containing dihydrofurans 5bg in good to excellent yield. Difluoroallylic benzylic ketones 2e and 2f gave 2-benzylidene dihydrofurans 5e and 5f, respectively. Reactions of difluoroallylic ketones 2hj, which possess a cyclohexane ring at the allylic position, constructed a spirocyclic structure in 5hj. The reactions of α,α,α′,α′-tetrasubstituted ketones 2g and 2j were sluggish under the same conditions. However, the longer reaction time or the use of pyridine as the solvent instead of THF improved the yields of 5g or 5j, respectively. Intriguingly, dihydrofuran derivatives 5af and 5i were obtained as single isomers about the exo double bond, judging from 1H NMR and 13C NMR studies. The configurations of 5af and 5i were assigned as Z-isomers by a NOESY experiment of 5b.[ 17 ] This Z-selectivity in the formation of dihydrofurans 5af and 5i is interpreted as follows: the Z-enolates seem to be generated predominantly by deprotonation of difluoro­allylic ketones 2 because of steric repulsion between substituents at both of the α positions of the carbonyl groups in 2. The subsequent cyclization presumably proceeds through the Z-enolates with retention of stereochemistry.

Difluoroallylic ketones 2, as shown in Table [2], underwent 5-endo-trig O-cyclization via their enolate forms. The reaction afforded the corresponding 2-alkylidene-5-fluoro-2,3-dihydrofurans 5 without the formation of C-cyclization products, 3-fluorocyclopent-3-en-1-ones 6. Although 5-endo-trig cyclization is assigned as disfavored in Baldwin’s rules,[ 5 ] the reactivity of 1,1-difluoro-1-alkenes ­allows the substrates to undergo such an extraordinary cyclization.

In summary, we have demonstrated that 3,3-difluoroallylic ketone enolates exclusively underwent intramolecular O-alkenylation to afford fluorinated dihydrofurans 5 bearing a Z-exo-alkylidene unit. The cyclization proceeded in a 5-endo-trig fashion, which is disfavored according to Baldwin’s rules. In this process, a fluorine substituent was introduced selectively onto the 5-position of the 2,3-dihydrofuran scaffold. Furthermore, since fluorinated 2-alkylidene-2,3-dihydrofurans are unprecedented and highly functionalized, it is expected that these compounds would serve as parts of bioactive molecules and versatile intermediates.[ 18 ]

Zoom
Figure 1 NOE correlation between protons in dihydrofuran 5b

Supporting Information



Zoom
Scheme 1Intramolecular cyclization of gem-difluoroalkenes
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Scheme 2 Synthesis of 3,3-difluoroallylic ketones 2
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Figure 1 NOE correlation between protons in dihydrofuran 5b