Synlett 2012; 23(16): 2413-2415
DOI: 10.1055/s-0032-1317157
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of β-Fluoro Amides Using Partially Hydrated Nickel Difluoride as Fluorine Source

Wan Xuan Zhang*
Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, P. R. of China   Fax: +86(27)88663043   Email: zhangwx@hubu.edu.cn
,
Li Su
Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, P. R. of China   Fax: +86(27)88663043   Email: zhangwx@hubu.edu.cn
,
Wei Gang Hu
Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, P. R. of China   Fax: +86(27)88663043   Email: zhangwx@hubu.edu.cn
,
Jie Zhou
Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, P. R. of China   Fax: +86(27)88663043   Email: zhangwx@hubu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 14 June 2012

Accepted after revision: 30 July 2012

Publication Date:
10 September 2012 (online)


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Abstract

β-Fluoro amides were obtained from the reactions of ­activated aziridines with partially hydrated nickel difluoride (NiF2·nH2O, n <4) in good yields (47–82%) in the presence of tetra-n-butylammonium fluoride (20 mol%), while the non-activated aziridines did not react under the same conditions.