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Synthesis 2012; 44(22): 3496-3504
DOI: 10.1055/s-0032-1316791
DOI: 10.1055/s-0032-1316791
paper
Synthetic Routes to a Series of Proximal and Distal 2′-Deoxy Fleximers
Further Information
Publication History
Received: 31 July 2012
Accepted after revision: 10 September 2012
Publication Date:
02 October 2012 (online)
Abstract
Two series of innovative 2′-deoxy nucleoside analogues have been designed where the nucleobase has been split into its imidazole and pyrimidine subunits. This structural modification serves to introduce flexibility into the nucleobase scaffold while still retaining the elements required for recognition. The synthetic efforts to realize these analogues are described within.
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