An Efficient Route to Difluoromethylated Pyridines

Abstract

A convenient route to difluoromethylated pyridines was developed that involves copper-promoted cross-coupling of halopyridines with ethyl difluoro(trimethylsilyl)acetate and subsequent decarboxylation.

Key words

fluorine - pyridines - copper - catalysis - cross-coupling - decarboxylations

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