Microwave-Assisted Copper-Catalyzed Cross-Coupling Reaction of Alkynes with Aryl Iodides and Vinyl Halides

Wen-Ting Tsai; Yun-Yung Lin; Yu-Jen Wang; Chin-Fa Lee

doi:10.1055/s-0031-1290813

Synthesis, Table of Contents

Synthesis 2012; 44(10): 1507-1510
DOI: 10.1055/s-0031-1290813

special topic

Microwave-Assisted Copper-Catalyzed Cross-Coupling Reaction of Alkynes with Aryl Iodides and Vinyl Halides

Wen-Ting Tsai

Department of Chemistry, National Chung Hsing University, Taichung, Taiwan 402, ROC, Fax: +886(4)22862547 Email: cfalee@dragon.nchu.edu.tw

,

Yun-Yung Lin

Department of Chemistry, National Chung Hsing University, Taichung, Taiwan 402, ROC, Fax: +886(4)22862547 Email: cfalee@dragon.nchu.edu.tw

,

Yu-Jen Wang

Department of Chemistry, National Chung Hsing University, Taichung, Taiwan 402, ROC, Fax: +886(4)22862547 Email: cfalee@dragon.nchu.edu.tw

,

Chin-Fa Lee*

Department of Chemistry, National Chung Hsing University, Taichung, Taiwan 402, ROC, Fax: +886(4)22862547 Email: cfalee@dragon.nchu.edu.tw

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Abstract

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Abstract

The microwave-assisted, copper-catalyzed coupling of terminal alkynes with aryl iodides and vinyl halides is reported. In general, the reactions are completed in 10–30 min using 2–5 mol% [CuI(xantphos)] as a catalyst to provide the corresponding alkynes and enynes in good to excellent yields. A broad spectrum of aryl iodides, vinyl iodides, and bromides are coupled with aryl- and alkyl alkynes.

Key words

microwaves - copper - cross-coupling - alkynes - aryl iodide

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References

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