The microwave-assisted, copper-catalyzed coupling of terminal alkynes with aryl iodides
and vinyl halides is reported. In general, the reactions are completed in 10–30 min
using 2–5 mol% [CuI(xantphos)] as a catalyst to provide the corresponding alkynes
and enynes in good to excellent yields. A broad spectrum of aryl iodides, vinyl iodides,
and bromides are coupled with aryl- and alkyl alkynes.
Key words
microwaves - copper - cross-coupling - alkynes - aryl iodide