Synthesis and Properties of Fluoropyrroles and Their Analogues

Olga V. Serdyuk; Vasiliy M. Muzalevskiy; Valentine G. Nenajdenko

doi:10.1055/s-0031-1289770

Synthesis, Table of Contents

Synthesis 2012; 44(14): 2115-2137
DOI: 10.1055/s-0031-1289770

review

Synthesis and Properties of Fluoropyrroles and Their Analogues

Olga V. Serdyuk

^aSouthern Federal University, Department of Chemistry, Zorge 7, Rostov-on-Don, 344090, Russian Federation, Fax: +7(863)2975146 Email: oserduke@mail.ru

,

Vasiliy M. Muzalevskiy

^bMoscow State University, Department of Chemistry, Leninskie Gory, Moscow, 119992, Russian Federation , Email: nen@acylium.chem.msu.ru

,

Valentine G. Nenajdenko*

^bMoscow State University, Department of Chemistry, Leninskie Gory, Moscow, 119992, Russian Federation , Email: nen@acylium.chem.msu.ru

› Author Affiliations

Abstract

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Abstract

Pyrroles and indoles are important subunits of many natural products and pharmacologically active compounds. Fluorinated compounds possess a unique complex of physical, chemical, and biological properties that results in their wide application as construction materials, liquid crystalline materials, agrochemicals, and drugs. The review covers the synthesis and properties of fluoropyrroles and their benzo analogues. The literature up to 2011 is highlighted.

1 Introduction

2 Synthesis of Fluoropyrroles

2.1 Functionalization of the Pyrrole Ring

2.2 Cycloaddition and Heterocyclization

2.3 Other Methods

3 Synthesis of Indoles, Indolizines and Deazopurines with Fluorinated Pyrrole Rings

3.1 Functionalization of the Pyrrole Ring

3.2 Heterocyclizations

4 Synthesis of Indoles with Fluorine Atoms on the Carbocycle

5 Properties of Fluorinated Pyrroles and Indoles

6 Conclusions

Key words

fluorine - heterocycles - pyrroles - indoles

Full Text

References

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