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Synthesis 2012; 44(10): 1491-1500
DOI: 10.1055/s-0031-1289760
DOI: 10.1055/s-0031-1289760
special topic
Oxidative Alkynylation of Imines with Alkynylcopper Reagents: A Straightforward and Practical Entry to Ynimines
Further Information
Publication History
Received: 29 February 2012
Accepted after revision: 07 March 2012
Publication Date:
12 April 2012 (online)
Abstract
We have developed an efficient and general synthesis of ynimines based on an oxidative cross-coupling between imines and alkynylcopper reagents. Upon simple addition of 1,2-dimethylimidazole in the presence of oxygen, these bench-stable, crystalline, and readily available polymeric compounds were found to be especially suitable reagents for the introduction of an alkynyl group into a wide range of ketimines at room temperature and under especially mild conditions.
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- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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