Abstract
A library of 5-aryl-4-methylpyrimidines, phenyl ring-substituted
derivatives of 4-benzylpyrimidines, 2,6-benzylpyridines, and 2,6-dibenzyl-4-methylpyridines
were prepared. The synthesis of 5-aryl-4-methylpyrimidines was accomplished
by Suzuki-Miyaura cross-coupling reaction between
arylboronic acids and 5-bromo-4-methylpyrimidine. The 4-benzylpyrimidines
and 2,6-benzylpyridines were synthesized by treatment of 4-bromopyrimidine
and 2,6-dibromopyridine derivatives with ring-substituted benzylzinc
reagents.
Key words
cross-coupling reaction - amphetamine analogues - Leuckart
synthesis - drugs - heterocycles
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