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Synthesis 2011(14): 2237-2246  
DOI: 10.1055/s-0030-1260062
SPECIALTOPIC
© Georg Thieme Verlag Stuttgart ˙ New York

New Heterocyclic Inputs for the Povarov Multicomponent Reaction

Esther Vicente-Garcíaa, Rosario Ramóna, Rodolfo Lavilla*a,b
a Barcelona Science Park, Baldiri Reixac 10-12, 08028, Barcelona, Spain
b Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Avda. Joan XXIII sn, 08028, Barcelona, Spain
Fax: +34(93)4037104; e-Mail: rlavilla@pcb.ub.es;
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Publication History

Received 28 March 2011
Publication Date:
09 June 2011 (online)

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Abstract

Oxa-, thia- and imidazolones are reactive inputs as electron-rich olefin components in Povarov reactions. On interaction with anilines and aldehydes, these substrates afford the corresponding multicomponent adducts in a regioselective manner. Intramolecular processes are also explored. Post-condensation oxidation provides convenient access to a variety of fused quinoline derivatives.

Key words

domino reaction - heterocycles - imines - multicomponent reaction - quinolines

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