Download PDF
Synfacts 2011(3): 0319-0319  
DOI: 10.1055/s-0030-1259422
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Nickel-Catalyzed Reductive Cleavage of Aryl Ethers

Contributor(s): Paul Knochel, Andreas K. Steib
P. Álvarez-Bercedo, R. Martín*
Institute of Chemical Research of Catalonia, Terragona, Spain
Further Information

Publication History

Publication Date:
16 February 2011 (online)

    Permissions and Reprints

Significance

A catalytic reductive cleavage of inert C-O bonds of aryl methyl ethers as removable directing groups is described. The method uses Ni(cod)2 in catalytic amounts and is achieved without using halogenated or tin-based precursors.