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Synfacts 2010(12): 1396-1396  
DOI: 10.1055/s-0030-1258900
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Ruthenium-Catalyzed Asymmetric Monohydrogenation of meso-Cyclic Imides

Contributor(s): Hisashi Yamamoto, Zhi Li
S. Takebayashi, J. M. John, S. H. Bergens*
University of Alberta, Edmonton, Canada
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Publikationsdatum:
22. November 2010 (online)

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Significance

This paper features the first asymmetric monohydrogenation of meso-cyclic imides. A variety of cyclic imides were selectively hydrogenated on one of the two carbonyls to generate ­hydroxyl lactams in high yields and stereoselectivities.