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Synfacts 2010(12): 1376-1376  
DOI: 10.1055/s-0030-1258899
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Nickel-Catalyzed Aldol Reaction Between α-Isothiocyanato Imide and Aldehydes

Contributor(s): Hisashi Yamamoto, Zhi Li
X. Chen, Y. Zhu, Z. Qiao, M. Xie, L. Lin, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
22 November 2010 (online)

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Significance

The authors of this paper describe a catalytic asymmetric aldol reaction between an α-isothiocyanato imide and various aldehydes catalyzed by nickel N,N′-dioxide complexes. The ­reaction exhibited high yield and stereoselectivity. The products were further converted into anti-β-hydroxy-α-amino acids in simple procedures.