An Eco-Sustainable Erbium(III)
Triflate Catalyzed Formation and Cleavage of tert-Butyl
Ethers

Antonio Procopio; Paola Costanzo; Massimo Curini; Monica Nardi; Manuela Oliverio; Rosina Paonessa

doi:10.1055/s-0030-1258332

PAPER

An Eco-Sustainable Erbium(III) Triflate Catalyzed Formation and Cleavage of tert-Butyl Ethers

Antonio Procopio*^a, Paola Costanzo^a, Massimo Curini^b, Monica Nardi^c, Manuela Oliverio^a, Rosina Paonessa^a
^a Dipartimento Farmaco-Biologico, Università degli Studi della Magna Græcia Complesso Ninì Barbieri, 88021 Roccelletta di Borgia (CZ), Italy
Fax: +39(0961)36955713; e-Mail: procopio@unicz.it;
^b Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Via del Liceo 1, 06123 Perugia (PG), Italy
^c Dipartimento di Chimica, Università della Calabria, Ponte Bucci, 87030 Arcavacata di Rende (CS), Italy

Abstract

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Abstract

An eco-compatible method, which permits the formation or cleavage of tert-butyl ethers of alcohols and phenols, is proposed. The protection step is performed in solvent-free conditions at room temperature using catalytic amount of Er(OTf)₃. The catalyst is easily recovered from the aqueous phase and reused several times without significant loss of activity. The deprotection step developed is also highly eco-friendly since the tert-butyl group is removed very quickly from alcohols and phenols in methanol using MW irradiation.

Key words

green chemistry - Lewis acid - protecting groups - tert-butyl ether - microwave heating

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References

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