Abstract
The bark of the rain forest tree Galbulimima
belgraveana has been identified as a rich source of fascinating
natural products and so far 28 unique alkaloids have been isolated.
The chemical interest in Galbulimima alkaloids started with the
discovery of the promising biological activities of himbacine. Fifteen
years after the first total synthesis of himbacine, this class of
natural product still inspires, with the structurally more complex
congeners himandrine, himgaline, and G.B. 13 as highly challenging
synthetic targets. This review article summarizes and discusses
all syntheses of Galbulimima alkaloids published to date.
1 Introduction
2 Syntheses of Galbulimima Alkaloids
2.1 Class I Alkaloids
2.2 Class II Alkaloids
2.3 Class III Alkaloids
3 Conclusion
Key words
Galbulimima alkaloids - natural products - total
synthesis - Diels-Alder reaction - heterocycles - fused-ring systems
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