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Synthesis 2010(17): 2884-2892
DOI: 10.1055/s-0030-1258184
DOI: 10.1055/s-0030-1258184
SPECIALTOPIC
© Georg Thieme Verlag
Stuttgart ˙ New YorkRhodium(I)-Catalyzed Hydroacylation/Cycloisomerization Cascade Reaction: Application to the Construction of the Tricyclic Core of Guanacastepenes
Further Information
Received
23 April 2010
Publication Date:
16 July 2010 (online)
Publication History
Publication Date:
16 July 2010 (online)
Abstract
We previously developed a novel rhodium(I)-catalyzed cascade reaction involving the hydroacylation of a 4,6-dienal followed by cycloisomerization of the resulting 1,3-diene with an alkene, giving carbocycles containing a bicyclo[5.3.0]decenone skeleton in a stereoselective manner. Herein, we report the construction of the C5,C7,C6-tricyclic core of guanacastepenes using this cascade reaction.
Key words
rhodium - cascade reactions - dienes - aldehydes - guanacastepenes
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