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DOI: 10.1055/s-0029-1218746
Synthesis of 2-(2-Dialkylamino-4H-3,1-benzothiazin-4-yl)acetic Acid Derivatives and 2-(2-Thioxo-1,2,3,4-tetrahydroquinazolin-4-yl)acetic Acid Derivatives
Publikationsverlauf
Publikationsdatum:
15. April 2010 (online)

Abstract
An efficient method for the preparation of 2-(4H-3,1-benzothiazin-4-yl)acetic acid derivatives and 2-(2-thioxo-1,2,3,4-tetrahydroquinazolin-4-yl)acetic acid derivatives has been developed. The reaction of 3-(2-isothiocyanatophenyl)propenoic acid derivatives with secondary amines in methanol at room temperature gave the corresponding thiourea intermediates, which on heating at reflux temperature cyclized by an attack of the sulfur atom on the propenoic moiety in a 1,4-addition manner, to give 2-(2-dialkylamino-4H-3,1-benzothiazin-4-yl)acetic acid derivatives in one pot. A similar sequence using primary amines in place of secondary amines afforded 2-[3-alkyl(or aryl)-2-thioxo-1,2,3,4-tetrahydroquinazolin-4-yl]acetic acid derivatives.
Key words
4H-3,1-benzothiazines - 2-thioxo-1,2,3,4-tetrahydroquinazolines - 3-(2-isothiocyanatophenyl)propenoic acids - thioureas - 1,4-addition
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