Palladium-Catalyzed Direct
Arylation-Based Domino Synthesis of Annulated N-Heterocycles
Using Alkenyl or (Hetero)Aryl 1,2-Dihalides

Lutz Ackermann; Andreas Althammer; Peter Mayer

doi:10.1055/s-0029-1216977

SPECIALTOPIC

Palladium-Catalyzed Direct Arylation-Based Domino Synthesis of Annulated N-Heterocycles Using Alkenyl or (Hetero)Aryl 1,2-Dihalides

Lutz Ackermann*^a, Andreas Althammer^a, Peter Mayer^b
^a Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstr. 2, 37077 Göttingen, Germany
Fax: +49(551)396777; e-Mail: Lutz.Ackermann@chemie.uni-goettingen.de;
^b Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München, Germany

Abstract

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Abstract

A palladium-catalyzed reaction sequence consisting of an intermolecular amination and an intramolecular direct arylation enabled highly regioselective syntheses of functionalized indoles or carbazoles and proved to be amenable to the use of inexpensive 1,2-dichloroarenes as electrophiles.

Key words

arylation - catalysis - heterocycles - palladium - sequential reaction

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Referenzen

References

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