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Synthesis 2009(11): 1881-1885  
DOI: 10.1055/s-0028-1088047
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Reduction of Prochiral Ketones Employing Sprouted Pisum sativa as Biocatalyst

Jhillu S. Yadav*, Basi V. Subba Reddy, Chittamuru Sreelakshmi, Adari Bhaskar Rao
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India
Fax: +91(40)27160512; e-Mail: yadavpub@iict.res.in;
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Publication History

Received 19 January 2009
Publication Date:
14 April 2009 (online)

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Abstract

Sprouted green peas have been used for the first time as biocatalysts for enantioselective reduction of prochiral ketones. The reactions are highly enantioselective to furnish chiral alcohols in good yields. The sprouted peas as biocatalysts are a cheap and easy way for generating some interesting chiral alcohols. This process is efficient and convenient to produce chiral secondary alcohols in water.

Key words

biocatalysis - ketones - enantioselective - chiral alcohols

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