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Synthesis 2009(7): 1062-1064  
DOI: 10.1055/s-0028-1088007
SHORTPAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Simple and Practical Method for the Oxidation of Thebaine to 14-Hydroxycodeinone by V2O5-H2O2

Saikat Das Sharma, Dilip Konwar*
Synthetic Organic Chemistry Division, North East Institute of Science & Technology (Formerly Regional Research Laboratory, Jorhat), Jorhat 785006, Assam, India
Fax: +91(376)2370011; e-Mail: dkonwar@yahoo.co.uk;
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Publikationsverlauf

Received 10 November 2008
Publikationsdatum:
06. März 2009 (online)

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Abstract

An efficient, practical and expeditious method has been developed for the oxidation of thebaine to 14-hydroxycodeinone in excellent yield by employing 20 mol% of V2O5 in the presence of 30% H2O2 in aqueous medium. The method provides a clean technological process for the preparation of a key drug intermediate, 14-hydroxycodeinone.

Key words

14-hydroxycodeinone - thebaine - vanadium pentoxide - hydrogen peroxide - catalytic oxidation

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