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Synthesis 2008(24): 3974-3980  
DOI: 10.1055/s-0028-1083245
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Copper(I) Iodide Catalyzed Domino Process to Quinazolin-4(3H)-ones

Jing Zhoua,b, Liangbing Fua,b,c, Man Lva,b, Jinsong Liub, Duanqing Peia,b, Ke Ding*a,b
a Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences International Business Incubator A-3, Guangzhou Science Park, Guangzhou 510663, P. R. of China
b State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences International Business Incubator A-3, Guangzhou Science Park, Guangzhou 510663, P. R. of China
Fax: +86(20)32290485; e-Mail: ding_ke@gibh.ac.cn;
c Graduate School of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, P. R. of China
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Publication History

Received 22 August 2008
Publication Date:
01 December 2008 (online)

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Abstract

An efficient synthesis of substituted quinazolin-4(3H)-ones by a one-pot ligand-free CuI-catalyzed coupling/condensative cyclization under mild conditions is described. Our study provides an alternative strategy for the preparation of biologically active quinazolin-4(3H)-ones.

Key words

quinazolin-4(3H)-ones - one-pot - ligand-free - copper(I) iodide - coupling/condensative cyclization

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CCDC # 701749 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge at www.ccdc.cam.ac.uk/conts/retrieving.html [or from the Cambridge Crystallographic Data Centre, 12, Union Road, Cambridge CB2 1EZ, UK; fax: +44(1223)336033; E-mail: deposit@ccdc.cam.ac.uk].