Synlett
DOI: 10.1055/a-2807-2860
Letter

Transfer Hydrogenation of Quinolines Catalyzed by Novel Cyclic Phosphorodiamidic Acid

Authors

  • Shilong Tian

    1   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China (Ringgold ID: RIN12676)
  • Jiawen Xiong

    1   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China (Ringgold ID: RIN12676)
  • Min Zhang

    1   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China (Ringgold ID: RIN12676)
  • Ting Zhao

    1   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China (Ringgold ID: RIN12676)
  • Panpan Yue

    1   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China (Ringgold ID: RIN12676)
  • Liuqing Yang

    1   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China (Ringgold ID: RIN12676)
  • Peng Liu

    1   School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, China (Ringgold ID: RIN12676)

This work was supported by the Natural Science Foundation of Jiangsu Province (Grants No BK20240836) and the Senior Talent Research Start-up Funding of Jiangsu University (Grants No 5501310017).
Supported by: Senior Talent Research Startup Funding of Jiangsu University 5501310017


Graphical Abstract

Abstract

Cyclic phosphorodiamidic acid is easy to be synthesized and used as Brønsted acid to catalyze hydrogenation of quinolines. The reaction conditions are mild and the substrate scope is wide with high yield. Several applications of this method have been realized, especially enantioselective synthesis with moderate results.

Primary Data



Publication History

Received: 02 December 2025

Accepted after revision: 05 February 2026

Accepted Manuscript online:
05 February 2026

Article published online:
27 February 2026

© 2026. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany