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DOI: 10.1055/a-2801-7481
Catalytic 1,2-Elimination: A Novel Asymmetric Approach
Authors
Abstract
Elimination reactions have unexpectedly emerged as a novel tool in asymmetric synthesis, offering unique and advantageous approaches for accessing diverse chiral structures. Recent advances in catalytic asymmetric 1,2-elimination reactions leading to carbon–carbon double bonds have been summarized and systematically discussed in three sections, according to distinct synthetic strategies such as desymmetrization to centrally chiral compounds, kinetic resolution of β-substituted carbonyl compounds, and β-elimination to axially chiral compounds. This brief review aims to highlight the significance and sophistication of these three specialized asymmetric elimination pathways in the innovative construction of chiral molecules, while also encouraging the continued growth of this emerging field.
Publication History
Received: 05 January 2026
Accepted after revision: 30 January 2026
Accepted Manuscript online:
30 January 2026
Article published online:
13 February 2026
© 2026. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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