Download PDF
Synlett
DOI: 10.1055/a-2798-3093
Synpacts

A Formal Aldehydic C–H Borylation

Authors

  • Jiaxin Lin

    1   Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, Hong Kong (Ringgold ID: RIN58207)

  • Yangjian Quan 

    1   Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong, Hong Kong (Ringgold ID: RIN58207)

Supported by: NSFC Young Scholar Fund 22301254
Funding Information The authors acknowledge the start-up funding (Project no.: R9804) from the Hong Kong University of Science and Technology (HKUST) and NSFC Young Scholar Fund (Project no.: 22301254).
Further Information
   Permissions and Reprints All articles of this category


Graphical Abstract

Abstract

Recent research has demonstrated a novel copper-catalyzed method for formal aldehydic C–H borylation utilizing a new sp2–sp3 diboron reagent, LBH2-Bpin. This approach provides a streamlined route to a wide range of acylboranes, which are valuable intermediates in medicinal chemistry. This Synpact article reviews the traditional synthetic methods of acylboranes and the uniqueness of this aldehydic C–H borylation protocol.

Keywords

Boron - Acylborane - C–H borylation - Hydrogen transfer - Diboron reagent


Publication History

Received: 12 November 2025

Accepted after revision: 27 January 2026

Article published online:
05 February 2026

© 2026. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany