Ruthenium-catalyzed C–H Sulfonamidation of 4-Aryl-7H-pyrrolo[2,3-d] pyrimidine with Sulfonyl Azides Under Aerobic Atmosphere

Abstract

Ruthenium-catalyzed arene ortho C−H sulfonamidation of 4-aryl-7H-pyrrolo[2,3-d]pyrimidine derivatives with sulfonyl azides under aerobic conditions is described. This transformation has the advantages of operational simplicity, good functional group compatibility, broad substrate scope, and mild conditions, affording a variety of sulfonamidated pyrrolo[2,3-d]pyrimidine derivatives in good to excellent yields. Oxygen plays a vital role in this unique reactivity.

Keywords

C–H sulfonamidation - Pyrrolo[2,3-d]pyrimidine - Sulfonyl azides - Site-selectivity - [RuCl₂(p-cymene)]₂ - Under aerobic conditions

Publication History

Received: 19 December 2025

Accepted after revision: 26 January 2026

Accepted Manuscript online:
27 January 2026

Article published online:
06 February 2026

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