A Practical Synthesis of 3-Ylidenephthalides by the Rh-Catalyzed Tandem Reactions of Benzoic acids and Alkynyl Chlorides

Abstract

A synthesis of 3-ylidenephthalides with high practicality and efficiency, using benzoic acids and alkynyl chlorides as substrate, was realized by the rhodium catalysis. The utilization of alkynyl chlorides enabled this reaction has advantages of broad substrates scope, mild reaction condition, high selectivity, and yields.

Keywords

3-Ylidenephthalide - Rh catalysis - C–H activation - Alkynyl chloride - Chemoselectivity

Publication History

Received: 12 November 2025

Accepted after revision: 08 January 2026

Accepted Manuscript online:
09 January 2026

Article published online:
26 January 2026

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