Synthesis of Sterically Hindered Allylboranes via Ru-Catalyzed Reductive Boration of Propargylic Acetates

Abstract

A ruthenium-catalyzed selective synthesis of sterically hindered allylboranes is disclosed. Starting from readily available propargylic acetates, this process proceeded via initial reduction to the corresponding allenes followed by α-selective hydroboration. The choice of a suitable catalyst that can catalyze both steps is crucial to success. This process enjoys easy substrate preparation. It serves as a promising starting point for the further development into more practical synthesis of valuable hindered allylboranes.

Keywords

Hydroboration - Allylborane - Ruthenium - Regioselectivity - Propargylic compound

Publication History

Received: 03 November 2025

Accepted after revision: 12 December 2025

Accepted Manuscript online:
12 December 2025

Article published online:
31 December 2025

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