Preparation of Chiral α-Aryl Ketones and Aldehydes via Ni-Catalyzed Asymmetric Cross-Electrophile Coupling

Abstract

The preparation of tertiary α-aryl acetals and ketals has been achieved through a Ni-catalyzed reductive cross-coupling approach, utilizing a readily available Ni/Biox catalytic platform. This reaction demonstrates effective enantioselective control over unactivated alkyl radicals adjacent to sterically bulky acetal and ketal groups. The resulting protected tertiary α-aryl ketones and aldehydes are configurationally stable, offering opportunities for further chemical manipulations.

Keywords

α-Aryl carbonyl - Ketals - Acetals - Ni-catalyzed - Reductive asymmetric coupling

Publication History

Received: 18 September 2025

Accepted: 17 October 2025

Accepted Manuscript online:
17 October 2025

Article published online:
19 November 2025

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