Nickel-Catalyzed Reductive Cross-Coupling of Chlorobismuths with Aryl Halides

Dedication

Dedicated to Professor Paul Knochel on the occasion of his 70th birthday.

Abstract

A straightforward and efficient method for the synthesis of valuable arylbismuthanes via nickel-catalyzed cross-electrophilic coupling of chlorobismuths with aryl halides has been reported. This cross-electrophile C(sp²)–Bi coupling reaction is conducted under mild reaction conditions and exhibits a broad substrate scope. Notably, the described protocol tolerates various sensitive functionalities including alcohol, nitrile, ester, ketone, and aldehyde. Moreover, the application of the generated arylbismuthanes to the Pd-catalyzed cross-coupling reaction is demonstrated.

Keywords

Cross-electrophilic coupling - Arylbismuthane - Aryl halide - C(sp²)–Bi coupling - Nickel catalyst

Publication History

Received: 11 July 2025

Accepted after revision: 11 August 2025

Accepted Manuscript online:
12 August 2025

Article published online:
01 September 2025

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