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Synthesis 2025; 57(21): 3295-3306
DOI: 10.1055/a-2681-5943
DOI: 10.1055/a-2681-5943
Paper
Published as part of the Special Topic Dedicated to Prof. Paul Knochel
Nickel-Catalyzed Reductive Cross-Coupling of Chlorobismuths with Aryl Halides
Authors
This work was supported by the Fundamental Research Funds for the Central Universities (22CX03031A).
Dedication
Dedicated to Professor Paul Knochel on the occasion of his 70th birthday.
Abstract
A straightforward and efficient method for the synthesis of valuable arylbismuthanes via nickel-catalyzed cross-electrophilic coupling of chlorobismuths with aryl halides has been reported. This cross-electrophile C(sp2)–Bi coupling reaction is conducted under mild reaction conditions and exhibits a broad substrate scope. Notably, the described protocol tolerates various sensitive functionalities including alcohol, nitrile, ester, ketone, and aldehyde. Moreover, the application of the generated arylbismuthanes to the Pd-catalyzed cross-coupling reaction is demonstrated.
Keywords
Cross-electrophilic coupling - Arylbismuthane - Aryl halide - C(sp2)–Bi coupling - Nickel catalystPublication History
Received: 11 July 2025
Accepted after revision: 11 August 2025
Accepted Manuscript online:
12 August 2025
Article published online:
01 September 2025
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