The Transformation of Alkyl- and Aryl-Sodium Reagents with Simple Amides for the Direct Synthesis of Ketones

Dedication

Dedicated to Prof. Paul Knochel with highest respect and ultimate gratitude.

Abstract

The transformation of alkyl and aryl sodium reagents with N-alkyl amides is described. The reaction sequence is initiated by an alkyl sodium reagent, which is generated in a flow reactor. The alkyl sodium reagent is either directly reacted with N-alkyl amides or used for the reaction with alkyl-substituted or alkoxy-substituted arenes to generate secondary sodium reagents which were then reacted with the amides to afford the desired ketones in moderate to good yields.

Keywords

Alkyl sodium - Alkylation - Amides - Ketones - Sodiation - Transsodiation

Publication History

Received: 01 June 2025

Accepted after revision: 26 June 2025

Article published online:
13 August 2025

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