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Synthesis 2025; 57(21): 3211-3226
DOI: 10.1055/a-2640-7616
DOI: 10.1055/a-2640-7616
Paper
Published as part of the Special Topic Dedicated to Prof. Paul Knochel
Hexafluoroisopropanol-Promoted Substitution Toward the Synthesis of Enantiopure Ferrocene Phosphines
Authors
Supported by: University of Carthage
Supported by: Tunisian Ministry of Higher Education and Scientific Research
Supported by: Université de Rennes
Supported by: Centre National de la Recherche Scientifique
Funding Information This work was supported by the Université de Rennes, the Centre National de la Recherche Scientifique, the University of Carthage, and the Tunisian Ministry of Higher Education and Scientific Research (grant for S.B.).
Abstract
Enantiopure ferrocene-based phosphorus derivatives represent an important class of compounds with multiple applications in organic synthesis and coordination chemistry. Here, we report how the use of hexafluoroisopropanol can favor pseudo-benzylic substitutions toward both bulky diphosphine ligands and phosphonate derivatives. While the former can be involved in the formation of metal complexes, the latter can be easily reduced to original enantiopure ferrocenic primary mono- and diphosphines.
Keywords
Ferrocene - Primary phosphine - Chirality - Hexafluoroisopropanol - Substitution - ComplexesPublication History
Received: 16 May 2025
Accepted after revision: 20 June 2025
Accepted Manuscript online:
20 June 2025
Article published online:
15 August 2025
© 2025. Thieme. All rights reserved.
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