Singultus als Leitsymptom

Ein anhaltender Singultus kann zu einer erheblichen Beeinträchtigung der Lebensqualität führen und auch Symptom einer schwerwiegenden Erkrankung sein. Die häufigste Ursache für einen chronischen Singultus ist der gastroösophageale Reflux. Die Liste weiterer potenziell zugrunde liegender Erkrankungen ist lang, da die Afferenzen des Schluckaufreflexes diffus im Thorax verteilt sind. Eine diagnostische Aufarbeitung sollte daher interdisziplinär durch Neurologen, Internisten und HNO-Ärzte erfolgen.

Publikationsverlauf

Artikel online veröffentlicht:
09. September 2025

• Literatur

• 1 Bakheet N, Fouad R, Kassem AM. et al. Persistent hiccup: A rare presentation of COVID-19. Respir Investig 2020; S2212–5345(20)30164–7
• 2 Prince G, Sergel M. Persistent hiccups as an atypical presenting complaint of COVID-19. Am J Emerg Med 2020; 38 (07) 1546.e5-1546.e6
• 3 Cai W, Xu G, Tian Z. et al. Cervical repetitive peripheral magnetic stimulation relieves idiopathic persistent hiccups: A preliminary study of case report. Medicine (Baltimore) 2022; 101 (43) e31324
• 4 Krishnakumar HN, Menon SR, Mirahmadizadeh A. et al. Forced inspiratory suction and swallow tool (FISST): an automation of Valsalva maneuver variants for therapeutic interventions. Expert Rev Med Devices 2023; 20 (12) 1027-1034
• 5 Waack A, Maddens ME, Maddens NJ. et al. Persistent Hiccups after Subthalamic Nucleus Deep Brain Stimulator Implantation for Parkinson's Disease: Case Report and Literature Review. Case Rep Neurol 2023; 15 (01) 153-162
• 6 Recio SZ, Abdennadher M. Intractable hiccups after VNS implantation: a case report. BMC Neurol 2023; 23 (01) 297
• 7 Launois S, Bizec JL, Whitelaw WA. et al. Hiccup in adults: an overview. Eur Respir J 1993; 6: 563-575
• 8 Chang FY, Lu CL. Hiccup: mystery, nature and treatment. J Neurogastroenterol Motil 2012; 18: 123-130
• 9 Mercadante S, Porzio G, Valle A. et al. Orphan symptoms in advanced cancer patients followed at home. Support Care Cancer 2013; 21: 3525-3528
• 10 Lee GW, Kim RB, Go SI. et al. Gender differences in hiccup patients: Analysis of published case reports and case-control studies. J Pain Symptom Manage 2016; 51: 278-283
• 11 Jatoi A. Palliating hiccups in cancer patients: moving beyond recommendations from Leonard the lion. J Support Oncol 2009; 7: 129-130
• 12 Lance JW, Bassil GT. Familial intractable hiccup relieved by baclofen. Lancet 1989; 2: 276-277
• 13 Hahn A, Neubauer BA. Epileptic diaphragm myoclonus. Epileptic Disord 2012; 14: 418-421
• 14 Federspil PA, Zenk J. Hiccup. HNO 1999; 47: 867-875
• 15 Patel V, Griffith NC, Blackwood E. et al. Spectrum disorder of neuromyelitis optica in a patient presenting with intractable vomiting and hiccups, transverse myelitis and acute encephalopathy. J Clin Neurosci 2012; 19: 1576-1578
• 16 Liu CC. Sedation-associated hiccups in adults undergoing gastrointestinal endoscopy and colonoscopy. WJG 2012; 18: 3595
• 17 Matsuura N. Hiccups due to Chiari type I malformation. CMAJ 2023; 195 (18) E652
• 18 Kaeley N, Datta SS, Sharma A. et al. Hiccups and Slurring of Speech: Atypical Presentation of High-Altitude Cerebral Edema. Cureus 2023; 15 (02) e34997
• 19 Lopez DJ, Kumar S. Stellate Ganglion Block for Intractable Hiccups Secondary to a Motor Vehicle Collision. Cureus 2023; 15 (04) e37030
• 20 Hao XT, Wang L, Yan B. et al. Intractable hiccup caused by spinal cord lesions in demyelination disease. J Spinal Cord Med 2013; 36: 711-714
• 21 Schorl M. Leserbrief zu: Singultus – Diagnostik und Therapie. Akt Neurol 2014; 41: 342
• 22 Chang JM, Hwang SJ, Kuo HT. et al. Fatal outcome after ingestion of star fruit (Averrhoa carambola) in uremic patients. Am J Kidney Dis 2000; 35 (02) 189-199
• 23 Nguyen V, Deeb K, Rathakrishnan R. Hiccups: You got to be kidney me!. SAGE Open Med Case Rep. 2020; 8: 2050313X20962641
• 24 Liao XX, Yang JH, Xing NZ. Intractable hiccup due to giant hydronephrosis: a rare case report and literature review. Int J Surg Case Rep 2020; 67: 134-138
• 25 Garrigues P, Giovansili B, Villard F. et al. Kyste rénal responsable d’un hoquet. Presse Med 2007; 36 (02) 239-242
• 26 Moretto EN, Wee B, Wiff en PJ. et al. Interventions for treating persistent and intractable hiccups in adults. Cochrane Database Syst Rev 2013; 1: CD008768
• 27 Ehret CJ, Martin N, Jatoi A. Baclofen for hiccups: a large mixed methods multisite study. BMJ Support Palliat Care 2023;
• 28 Mei M, Fang M, Mao Y. et al. Single-arm trial to evaluate the efficacy and safety of baclofen in treatment of intractable hiccup caused by malignant tumor chemotherapy. Open Med (Wars) 2023; 18 (01) 20230664
• 29 Sangeetha RP, Srinivasaiah B, Sudhir V. et al. Amantadine for the intractable hiccup when weaning a patient with a brainstem lesion-a case study.. Indian J Anaesth 2023; 67 (09) 835-837
• 30 Go I S-, Koo D-H, Kim ST. et al. Antiemetic corticosteroid rotation from dexamethasone to methylprednisolone to prevent dexamethasone-induced hiccup in cancer patients treated with chemotherapy: a randomized, single-blind, crossover phase III trial. Oncologist 2017; 22: 1354-1361
• 31 Santini D, Armento G, Giusti R. et al. Management of orphan symptoms: ESMO Clinical Practice Guidelines for diagnosis and treatment. ESMO Open 2020; 5 (06) e000933
• 32 Latifa K, Ibrahim Al Ali M, Areen H. et al. Hydrocortisone Therapy in Post-Stroke Management of Persistent Hiccups: A Case Report. Cureus 2024; 16 (03) e56800
• 33 Noda S, Yamaguchi J, Kosugi K. et al. Peppermint Inhalation Therapy for Persistent Hiccups in Terminally Ill Cancer Patient: A Case Study. J Pain Symptom Manage 2024; 67 (05) e503-e505
• 34 Fodstad H, Nilsson S. Intractable singultus: a diagnostic and therapeutic challenge. Br J Neurosurg 1993; 7: 255-260
• 35 Brain WR. Epidemic hiccup and encephalitis lethargica: Report of a case of epidemic encephalitis showing lethargy, cranial nerve palsies, myoclonus, and hiccup. Br Med J 1923; 2: 856-857