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Synthesis
DOI: 10.1055/a-2600-4572
DOI: 10.1055/a-2600-4572
paper
Iron-Catalyzed P(O)–S Bond Formation through Cross-Dehydrogenative Coupling of Thiols with P(O)H Compounds
This work was financially supported by the National Science Foundation of China (22301164, 22425108, and 82404420), the Natural Science Foundation of Shandong Province (ZR2022QB007, ZR2024MB056, and ZR2023QH409), the Taishan Scholar Project of Shandong Province, and Shenzhen Special Funds (JCYJ20220530141205011).
Abstract
We herein report an iron(salan)-catalyzed cross-dehydrogenative coupling of thiols with P(O)H compounds for the efficient synthesis of a range of thiophosphates, thiophosphinates, and thiophosphinites. This mild and practical method employs environmentally benign air as terminal oxidant, and earth-abundant metal iron at a low loading as catalyst, and exhibits broad substrate scope and good functional group tolerance, which is applicable to bioactive molecule preparation.
Key words
iron catalysis - P(O)–S bond formation - cross-dehydrogenative coupling - thiophosphates - synthetic methodsSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2600-4572.
- Supporting Information
Publication History
Received: 27 March 2025
Accepted after revision: 05 May 2025
Accepted Manuscript online:
05 May 2025
Article published online:
11 June 2025
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