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Synthesis 2025; 57(14): 2197-2206
DOI: 10.1055/a-2591-8986
DOI: 10.1055/a-2591-8986
paper
Synthesis of Benzofuro[3,2-c]isoquinolines through Anionic Intramolecular Cyclization
Authors
We thank the National Natural Science Foundation of China (22271268) for financial support.
Abstract
Benzofuro[3,2-c]isoquinolines are among the typical tetraheterocycles. The synthesis of benzofuro[3,2-c]isoquinoline derivatives in the presence of a catalytic amount of KOH has been developed. A variety of substituents could be tolerated. The base (KOH) works as a catalyst. A gram-scale synthesis was performed. Control experiments confirmed that a cascade anionic annulation is involved rather than a radical cyclization.
Key words
base - cascade annulation - tetraheterocycles - benzofuro[3,2-c]isoquinolines - transition-metal-free - catalyst freeSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2591-8986.
- Supporting Information (PDF)
Publication History
Received: 16 March 2025
Accepted after revision: 21 April 2025
Accepted Manuscript online:
21 April 2025
Article published online:
08 May 2025
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