Directing Hydrogen Isotope Exchange with Aryl Carboxylic Acids

Abstract

A highly effective and selective ortho-directed hydrogen isotope exchange process for aryl carboxylic acids has been achieved by using an iridium(I) N-heterocyclic carbene/phosphine complex under mild and neutral conditions. Good levels of deuterium incorporation have been delivered across a wide array of examples, including a number of biologically active drug compounds.

Key words

iridium catalysis - hydrogen isotope exchange - deuteration - carboxylic acids - benzoic acids

Publication History

Received: 24 November 2023

Accepted after revision: 05 January 2024

Accepted Manuscript online:
05 January 2024

Article published online:
05 February 2024

• References and Notes

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