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Synthesis 2024; 56(14): 2234-2238
DOI: 10.1055/a-2235-5080
DOI: 10.1055/a-2235-5080
paper
Short Synthesis of Dopamine Agonist Rotigotine
Authors
The authors thank the Council of Scientific and Industrial Research (CSIR), C.S. thanks the University Grants Commission (UGC), and SK thanks CSIR for a research fellowship. S. C. thanks the Science and Engineering Research Board (SERB), Government of India for J C Bose fellowship (SB/S2/JCB-002/2015).
Abstract
A practical and short synthesis of FDA approved drug, Rotigotine, is achieved in two steps from 5-methoxy-2-tetralone, which in turn was synthesised by [4+2] cycloaddition of the in situ generated methoxyaryne from its precursor aryl triflate with benzyloxybutadiene or from 4-methoxyindanone via ring expansion using trimethylsilyldiazomethane.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2235-5080.
- Supporting Information (PDF)
Publikationsverlauf
Eingereicht: 10. November 2023
Angenommen nach Revision: 27. Dezember 2023
Accepted Manuscript online:
27. Dezember 2023
Artikel online veröffentlicht:
29. Januar 2024
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