Synthesis of an Alternating Polycation with the Dense 1,2,3-Triazole Backbone

Tomoki Omae; Masaki Nakahata; Yuri Kamon; Akihito Hashidzume

doi:10.1055/a-2214-5397

Synlett, Table of Contents

Synlett 2024; 35(11): 1301-1305
DOI: 10.1055/a-2214-5397

cluster

Japan/Netherlands Gratama Workshop

Synthesis of an Alternating Polycation with the Dense 1,2,3-Triazole Backbone

Tomoki Omae

^aDepartment of Macromolecular Science, Graduate School of Science, Osaka University, Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan

,

Masaki Nakahata

^aDepartment of Macromolecular Science, Graduate School of Science, Osaka University, Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan

,

Yuri Kamon

^bAdministration Department, Graduate School of Science, Osaka University, Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan

,

Akihito Hashidzume ∗

^aDepartment of Macromolecular Science, Graduate School of Science, Osaka University, Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan

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Abstract

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Abstract

Polycations are an important class of water-soluble polymers because they form polyion complexes with DNA. Thus, the synthesis of polycations with controlled monomer sequences will be of increasing importance for the formation of well-defined polyion complexes. In this study, cationic homopolymer and alternating copolymer with the dense triazole backbone were synthesized by copper(I)-catalyzed azide–alkyne cycloaddition polymerization. The polycations obtained were characterized by potentiometric and turbidimetric titrations, and by complex formation with poly(acrylic acid).

Key words

alternating copolymers - polycations - dense triazole backbone - copper(I)-catalyzed azide–alkyne cycloaddition - heterodimers

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