Abstract
Fluoroalkylthio groups have received substantial attention in the past decade because
of their unique physicochemical characteristics, and methods for incorporating these
substituents into organic molecules have been rapidly developed in recent years. This
account summarizes our efforts on the development of direct fluoroalkylthiolation
with fluoroalkanesulfite derivatives. Several innovative and efficient strategies
for the fluoroalkylthiolation of various substrates are disclosed, leading to various
valuable fluoroalkylthiolated compounds in good yields.
1 Introduction
2 Fluoroalkylthiolation with Sodium Fluoroalkanesulfinate
3 Fluoroalkylthiolation with Fluoroalkanesulfonyl Chloride
4 Fluoroalkylthiolation with Other Fluoroalkanesulfite Derivatives
5 Conclusion
Key words
trifluoromethylthiolation - difluoromethylthiolation - organofluorine compounds -
sodium trifluoromethylsulfinate - trifluoromethylsulfonyl chloride
