Recent Progress towards the Transition-Metal-Catalyzed Dearomatizing Spirocyclization Reactions of Indolyl Ynones

Kua-Fei Wei; Xiao-Lei Jiang; Guang-Xin Ru; Xiu-Hong Zhu; Wen-Bo Shen

doi:10.1055/a-1970-4290

Synlett, Table of Contents

Synlett 2023; 34(03): 211-220
DOI: 10.1055/a-1970-4290

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Recent Progress towards the Transition-Metal-Catalyzed Dearomatizing Spirocyclization Reactions of Indolyl Ynones

Kua-Fei Wei

^aCollege of Sciences and College of Forestry, Henan Agricultural University, Zhengzhou 450002, P. R. of China

,

Xiao-Lei Jiang

^aCollege of Sciences and College of Forestry, Henan Agricultural University, Zhengzhou 450002, P. R. of China

^bSanmenxia Polytechnic, Sanmenxia, Henan 472000, P. R. of China

,

Guang-Xin Ru

^aCollege of Sciences and College of Forestry, Henan Agricultural University, Zhengzhou 450002, P. R. of China

,

Xiu-Hong Zhu

^aCollege of Sciences and College of Forestry, Henan Agricultural University, Zhengzhou 450002, P. R. of China

,

Wen-Bo Shen∗

^aCollege of Sciences and College of Forestry, Henan Agricultural University, Zhengzhou 450002, P. R. of China

› Author Affiliations

Abstract

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Abstract

Dearomatizing spirocyclization reactions are very appealing synthetic strategies to generate functionalized three-dimensional scaffolds from simple two-dimensional precursors. Recently, the field of transition-metal-catalyzed dearomatizing spirocyclization reactions of indolyl ynones has burgeoned, as the construction of synthetically challenging quaternary spirocyclic carbons is easily achieved. In this review, we introduce an overview of advances in the transition-metal-catalyzed dearomatizing spirocyclization reactions of indolyl ynones, with the reactions being categorized according to type of catalyst.

Key words

transition-metal catalysis - indolyl ynones - dearomatization - spirocyclization - spirocyclic indolenines

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