Abstract
Stereoselective construction of conjugated dienes and polyenes has remained an enduring
synthetic problem owing to the central roles these compounds play in natural product
synthesis, methodology, and medicine. This review focuses on recent developments in
dienylation as an emerging strategy for the direct installation of unsaturated four-carbon
units of conjugated π-systems, outlining the regio- and stereoselectivity, as well
as the synthetic scope of reactions with various dienylating reagents and the mechanistic
implications of the catalytic cross-coupling processes that are used to enable dienylation.
1 Introduction
2 Sulfolenes
3 1,3-Dienes
4 Small-Ring Dienylation Reagents
5 Pyrones, Alkynes, and Homoallenylboronates
6 Conclusion and Outlook
Key words
cross-coupling - dienylation - 1,3-dienes - polyenes - stereoselectivity