Palladium-Catalyzed Synthesis of Aryl Ketones from Carboxylic Acids and Arylboronic Acids Using 2-Chloroimidazolium Chloride as a Coupling Reagent

Abstract

Carboxylic acids are an abundant and structurally diverse class of commercially available materials, which are commonly used as stable reagents in organic synthesis. The Suzuki–Miyaura coupling reaction directly using carboxylic acid as a substrate has been rarely reported. Here, we report an efficient coupling reaction of carboxylic acids with arylboronic acids in toluene in the presence of IPrCl-Cl, Pd(OAc)₂, PPh₃, and K₃PO₄·7H₂O at 90 °C to give the corresponding aryl ketones.

Key words

aryl ketones - carboxylic acids - arylboronic acids - IPrCl-Cl - palladium

Publication History

Received: 11 April 2022

Accepted after revision: 10 May 2022

Accepted Manuscript online:
10 May 2022

Article published online:
23 June 2022

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