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Synlett 2022; 33(01): 27-33
DOI: 10.1055/a-1662-7783
DOI: 10.1055/a-1662-7783
account
Long Journey on Daptomycin
I would like to express my gratitude to the funding agency for their generous supports over the years, including the Research Grants Council, University Grants Committee of Hong Kong (Grant Numbers C7038-15G, C5036-16G, and AoE/P-705/16), the Cubist Pharmaceutical Inc., the Peacock Program – Project Development Fund of Shenzhen, the National Basic Research Program of China, and the University of Hong Kong.
Abstract
Over the past more than ten years, my laboratory has been engaged in the total synthesis, medicinal chemistry, and chemical biology studies on daptomycin. Our efforts are expected to advance new understanding of this effective cyclic lipodepsipeptide antibiotic. In this Account, this long journey is presented.
1 Introduction
2 Total Synthesis of Daptomycin
3 Medicinal Chemistry of Daptomycin
4 Molecular Comparison of Daptomycin and Kynomycin
5 New Insight into How Daptomycin Exerts Bactericidal Effect
6 Conclusion
Publikationsverlauf
Eingereicht: 03. September 2021
Angenommen nach Revision: 06. Oktober 2021
Accepted Manuscript online:
06. Oktober 2021
Artikel online veröffentlicht:
26. Oktober 2021
© 2021. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
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There were two patents filed on the total synthesis of daptomycin, see: