Direct Copper-Catalyzed C-3 Arylation of Diphenylphosphine Oxide Indoles

Xiao-Ling Huang; Chong Li; Juan Wang; Shang-Dong Yang

doi:10.1055/a-1633-8792

Synthesis, Table of Contents

Synthesis 2022; 54(21): 4711-4720
DOI: 10.1055/a-1633-8792

special topic

Asymmetric C–H Functionalization

Direct Copper-Catalyzed C-3 Arylation of Diphenylphosphine Oxide Indoles

Xiao-Ling Huang

^aState Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China

,

Chong Li

^aState Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China

,

Juan Wang

^aState Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China

,

Shang-Dong Yang ∗

^aState Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. of China

^bState Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Lanzhou 730000, P. R. of China

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Abstract

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Abstract

We have developed a simple and effective method for the C-3 arylation of phosphorus-containing indole compounds in the presence of CuI under mild conditions. This reaction provides a reliable method for the modification of ligands.

Key words

transition-metal catalysis - organophosphorus compounds - arylation - indoles

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References

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