p-Toluenesulfonic Acid-Catalyzed Reaction of Phthalaldehydic Acids with Difluoroenoxysilanes: Access to 3-Difluoroalkyl Phthalides

Abstract

A convenient approach for the synthesis of 3-difluoroalkyl phthalides has been developed from phthalaldehydic acids and difluoroenoxysilanes by using relatively inexpensive p-toluenesulfonic acid monohydrate (PTSA) as a catalyst. A series of 3-difluoroalkyl phthalides and cyclic difluoroalkyl ethers were obtained in up to 99% yield. The products obtained could be readily converted into difluoroalkyl phthalide derivatives by simple modifications.

Key words

p-toluenesulfonic acid monohydrate - catalyst - phthalaldehydic acid - difluoroenoxysilane - 3-difluoroalkyl phthalide

Publication History

Received: 17 June 2021

Accepted after revision: 09 August 2021

Accepted Manuscript online:
09 August 2021

Article published online:
09 September 2021

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