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Synthesis 2021; 53(20): 3799-3814
DOI: 10.1055/a-1523-1409
DOI: 10.1055/a-1523-1409
paper
Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity
This program was co-funded by the European Union within the framework of the Operational Programm ERDF/ESF 2014–2020 and by the Regional Council of Normandy (RIN ChemImaging).
Abstract
Aminothiaindanone heterocycle appears to be a scaffold of interest in medicinal chemistry. To increase the chemical diversity in this series, the introduction of three-point chemical diversity on the cyclopenta[b]thiophen-4-one scaffold was explored. About thirty newly functionalized thiophene-containing bicycles were obtained using various chemical reactions, paving the way for novel possibilities in medicinal chemistry projects.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1523-1409.
- Supporting Information
Publication History
Received: 26 April 2021
Accepted after revision: 04 June 2021
Accepted Manuscript online:
04 June 2021
Article published online:
13 July 2021
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