Abstract
Sulfinamides, especially enantiopure sulfinamides, are widely used in organic and
medicinal synthesis. Syntheses and transformations of racemic and enantioenriched
sulfinamides have achieved great progress. Especially sulfinamides demonstrate interesting
and valuable reactivity, which deserves to be pertinent. This review summarizes the
latest development in the synthesis and transformation of sulfinamides and will be
helpful for future related research.
1 Introduction
2 Synthesis of Sulfinamides
2.1 Synthesis of Racemic Sulfinamides
2.2 Synthesis of Enantiomerically Pure Sulfinamides
2.3 Synthesis of Other Sulfinamides
3 Transformations of Sulfinamides
3.1 Condensation with Aldehydes and Ketones
3.2 Reaction with Alkynes
3.3 Reaction with Alkenes
3.4 Reaction with Aryl and Alkyl Halides
3.5 Reaction with Alcohols, Dibenzyl Ether, and Benzyl Mercaptan
3.6 Synthesis of tert-Butyldisulfanyl-Substituted Hetarenes
3.7 Synthesis of Asymmetric Sulfides
3.8 Synthesis of N-Phosphino-sulfinamide Ligands
3.9 Asymmetric Synthesis of γ-Amino Acids
3.10 Sulfonylation of Heterocyclic Compounds
4 Summary and Outlook
Key words
sulfinamides - organic synthesis - transformation - organosulfur chemistry - chiral
synthesis
