Dtsch Med Wochenschr 2020; 145(15): 1074-1079
DOI: 10.1055/a-1164-4323
Dossier

COVID-19 aus Sicht der Neurologie

COVID-19: A neurological point-of-view
Ole J. Simon
,
Lars Timmermann

Abstract

Evidence of neurological complications and direct affection of neuronal structures in the course of infections with SARS-CoV-2 is actually emerging. Therefore adequate medical care for neurological patients must also be guaranteed as part of the current SARS-CoV-2 pandemic. Multiple, peripheral and central neurological affections have been described, such as particular headache, consciousness disorders, cranial nerve disorders, peripheral nerve damage, epileptic seizures and ischemic events. Since abundant information on COVID-19 is published on a daily basis, this article aims to summarize and evaluate the current literature on this topic.

Die COVID-19-Erkrankung zeigt sowohl direkte als auch indirekte Affektionen des zentralen und peripheren Nervensystems. Dieser Beitrag gibt einen Überblick über die bekannten Symptome, Komplikationen und Besonderheiten der SARS-CoV-2-Infektion aus neurologischer Sicht.



Publication History

Article published online:
30 July 2020

© Georg Thieme Verlag KG
Stuttgart · New York

 
  • Literatur

  • 1 Xu J, Zhong S, Liu J. et al Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis. Clin Infect Dis 2005; 41: 1089-1096 . doi:10.1086/444461
  • 2 Gu J, Gong E, Zhang B. et al Multiple organ infection and the pathogenesis of SARS. J Exp Med 2005; 202: 415-424 . doi:10.1084/jem.20050828
  • 3 Desforges M, Le Coupanec A, Dubeau P. et al Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?. Viruses 2019; 12
  • 4 Hung EC, Chim SS, Chan PK. et al Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome. Clin Chem 2003; 49: 2108-2109 . doi:10.1373/clinchem.2003.025437
  • 5 Mao L, Jin H, Wang M. et al Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol 2020;
  • 6 Daou BJ, Koduri S, Palmateer G. et al Letter: Neurological Implications of COVID-19 and Lessons Learned From Prior Epidemics and Pandemics. Neurosurgery 2020;
  • 7 Sepehrinezhad A, Shahbazi A, Negah SS. COVID-19 virus may have neuroinvasive potential and cause neurological complications: a perspective review. J Neurovirol 2020;
  • 8 Netland J, Meyerholz DK, Moore S. et al Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 2008; 82: 7264-7275 . doi:10.1128/JVI.00737-08
  • 9 Baig AM, Khaleeq A, Ali U. et al Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms. ACS Chem Neurosci 2020; 11: 995-998 . doi:10.1021/acschemneuro.0c00122
  • 10 Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. J Med Virol 2020;
  • 11 Reynolds HR, Adhikari S, Pulgarin C. et al Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19. N Engl J Med 2020;
  • 12 Mancia G, Rea F, Ludergnani M. et al Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19. N Engl J Med 2020;
  • 13 Coperchini F, Chiovato L, Croce L. et al The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system. Cytokine Growth Factor Rev 2020;
  • 14 Lechien JR, Chiesa-Estomba CM, Place S. et al Clinical and Epidemiological Characteristics of 1420 European Patients with mild-to-moderate Coronavirus Disease 2019. J Intern Med 2020;
  • 15 Lechien JR, Chiesa-Estomba CM, De Siati DR. et al Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020;
  • 16 Dinkin M, Gao V, Kahan J. et al COVID-19 presenting with ophthalmoparesis from cranial nerve palsy. Neurology 2020;
  • 17 Gutiérrez-Ortiz C, Méndez A, Rodrigo-Rey S. et al Miller Fisher Syndrome and polyneuritis cranialis in COVID-19. Neurology 2020;
  • 18 Padroni M, Mastrangelo V, Asioli GM. et al Guillain-Barré syndrome following COVID-19: new infection, old complication?. J Neurol 2020;
  • 19 Alberti P, Beretta S, Piatti M. et al Guillain-Barré syndrome related to COVID-19 infection. Neurol Neuroimmunol Neuroinflamm 2020; 7
  • 20 Zhao H, Shen D, Zhou H. et al Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence?. Lancet Neurol 2020; 19: 383-384 . doi:10.1016/S1474-4422(20)30109-5
  • 21 Helms J, Kremer S, Merdji H. et al Neurologic Features in Severe SARS-CoV-2 Infection. N Engl J Med 2020;
  • 22 Bernard-Valnet R, Pizzarotti B, Anichini A. et al Two patients with acute meningo-encephalitis concomitant to SARS-CoV-2 infection. Eur J Neurol 2020;
  • 23 Moriguchi T, Harii N, Goto J. et al A first case of meningitis/encephalitis associated with SARS-Coronavirus-2. Int J Infect Dis 2020; 94: 55-58 . doi:10.1016/j.ijid.2020.03.062
  • 24 Al Saiegh F, Ghosh R, Leibold A. et al Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke. J Neurol Neurosurg Psychiatry 2020;
  • 25 Poyiadji N, Shahin G, Noujaim D. et al COVID-19-associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features. Radiology 2020;
  • 26 Zhang Y, Xiao M, Zhang S. et al Coagulopathy and Antiphospholipid Antibodies in Patients with Covid-19. N Engl J Med 2020; 382: e38 . doi:10.1056/NEJMc2007575
  • 27 Lodigiani C, Iapichino G, Carenzo L. et al Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thromb Res 2020; 191: 9-14 . doi:10.1016/j.thromres.2020.04.024
  • 28 Klok FA, Kruip MJHA, van der Meer NJM. et al Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res 2020;
  • 29 Oxley TJ, Mocco J, Majidi S. et al Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. N Engl J Med 2020;
  • 30 Beyrouti R, Adams ME, Benjamin L. et al Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry 2020;